Sentence examples for molecular reprogramming of from inspiring English sources

This flexibility in the differentiation hierarchy is commonly known as lineage plasticity [3] and is perhaps most dramatically demonstrated by molecular reprogramming of adult somatic cells into so-called induced pluripotent stem (iPS) cells [10], which express the genetic and phenotypic characteristics of pluripotent ES cells.

We further found that Tfcp2l1 is both necessary and sufficient to direct molecular reprogramming of post-implantation epiblast stem cells to naïve pluripotency.

It appears that in the course of PD mesothelial cells upregulate transcription factors of the snail, ZEB, and Twist families, which control molecular reprogramming of EMT [ 34].

Strikingly, the concerted activity of only four transcription factors (OCT4, SOX2, KLF-4 and c-Myc) is sufficient to initiate the molecular reprogramming of animal somatic cells to a pluripotent state in vitro (Takahashi and Yamanaka, 2006).

According to the EMT, there is a molecular reprogramming of the cancer cells that lose their epithelial features and acquire mesenchymal characteristics and become able to move away from the primary tumor and give metastases, by invading stroma and vessels [ 31, 32].

In M1 challenged cells, 627 genes were found to be upregulated at least 1.5-fold (all evidencing an FDR value lower than 0.05) and 1,246 genes were found to be downregulated at least 1.5-fold (all evidencing an FDR value of 0.05 or lower), suggesting an extensive molecular reprogramming of cell physiology.

Molecular reprogramming as part of the epithelial mesenchymal transition (EMT) is considered to be a crucial step involved in this process in most carcinomas.

These findings indicate that the contribution of Stat3 to molecular reprogramming extends beyond any induction of Klf4 or Nanog.

These findings indicate that Jak/Stat3 participate directly in molecular reprogramming and that activation of this pathway is a limiting component.

Molecular reprogramming, as a part of the epithelial mesenchymal transition (EMT), is considered to be a crucial step in the metastasis process of most carcinomas [ 5].

Together, these data indicate that Nanog acts at the final stage of the molecular reprogramming process to instate pluripotency.