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We discuss the impact of intrinsic molecular processes on mutation acquisition in cancer.
To simulate molecular processes on biologically relevant length- and timescales, coarse-grained (CG) models of biomolecular systems with tens to even hundreds of residues per CG site are required.
With that, it has the potential to supplement classical histochemical protocols and to provide new insights about molecular processes on the cellular level.
Pathophysiologically relevant molecular processes on the membrane and protein level and their association with functionally relevant parameters have not been addressed as yet.
Because molecular processes on the membrane surfaces of live cells and the surfaces of intracellular organelles are largely unknown, HS-AFM will certainly also be intensely applied to provide novel insight into these topics in the near future.
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Gianoulis et al. (2009) suggested that focusing on the molecular processes of the ecosystem as a whole provided more information than focusing on species composition.
Analyzing the entangled molecular processes of a microbial community on the level of segmented, gene-centric interaction networks allows identification of core molecular processes and functionalities adding to our mechanistic understanding of emergent properties of microbial consortia.
The effect of cART on the molecular processes of metabolic disturbances has been extensively studied [ 36] and its contribution to an increased risk of premature and accelerated atherosclerosis in HIV infection is well recognized [ 37, 38].
Reverse-pharmacokinetic methods (Brightman et al. 2006) can be used to predict oral doses that would be required to trigger molecular processes, for instance, based on half maximal inhibitory concentrations (IC50) for receptor binding from in vitro assays.
This integrates biological data from nanometer-scale molecular processes to genetic variation based on kilometer-scale geographic distributions.
Moreover, model-fitting methods do not allow one to distinguish between those molecular processes acting on short STRs because these methods work on the net product of various forms of mutations (i.e., point mutation, slippage, and indel slippage).
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