Sentence examples for molecular pathway activation from inspiring English sources

Our study provides an integral overview of genetic aberrations and molecular pathway activation in medulloblastoma.

In gene-expression microarray analysis, signature-based approach, in contrast to single gene-based approach, has been successfully utilized for robust identification of molecular pathway activation, prediction of disease phenotype and outcome, monitoring of response to genetic or pharmacologic experimental perturbations [2], [10], [20] [22].

Gene expression profiling approaches have highlighted the molecular heterogeneity of breast cancer [ 1], and identified gene expression fingerprints of molecular pathway activation [ 2].

Gene expression signatures of molecular pathway activation derived from perturbation experiments in model systems as well as structural models of molecular interactions ("model signatures") constitute an important resource for estimating corresponding activation levels in tumours.

Similarly, different mutations in KRAS, even if in the same codon such as G12C, G12V, and G12D mutations in the KRAS gene, may lead to different conformational changes in KRAS and have different effects on clinical outcomes and molecular pathway activation [ 39].

The effect of NT on LPS-induced molecular pathway activation, under either 10 or 30 mM glucose, was assessed by measuring the levels of the phosphorylated forms of MAP kinases (p38 MAPK, p44/42 MAPK, and SAPK/JNK) and PKB/AKT by western blot.

We define a molecular pathway wherein activation of SXR inhibits proliferation of estrogen receptor positive (ER+) and p53 wild type (p53wt) breast cancer cell lines (MCF-7 and ZR-75-1) vinductioniof of inducible nitric oxide synthase (iNOS), increased expression of nitric oxide (NO), and NO-dependent stabilization and accumulation of p53.

His laboratory has used various imaging systems to dissect several endogenous molecular pathways, including activation of hypoxia-inducible factor α in xenografts using a hypoxia-responsive promoter that drives expression of green fluorescent protein.

In summary, our findings indicate that a molecular pathway involving SSH1 Cofilin activation via direct engagement of lower-activation conformers of β1-integrin is essential for both A β42O-induced mitochondrial and synaptic dysfunction in AD.

The main objectives are the discovery of -dominant molecular alterations, -signalling pathway activation, and -tumor micro-environment patterns that may predict response or resistance to treatment.

Further investigation to determine the molecular basis of pathway activation is needed to help understand if it is playing a role in disease development.