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Our approach enables exploring shared etiologies of comorbid diseases at the molecular pathway level.
Finally, four issues need to be addressed: First, we only included the usage of information on the genetic, proteomic, metabolomic and molecular pathway level as means of PM.
The 160 and 37-gene sets were also compared at the ontology and molecular pathway level using the Fatigo tool for identifying significant associations between groups of genes [ 28].
Those means – usage of information on the genetic, proteomic, metabolomic and molecular pathway level – are adequately distinctive and can, furthermore, be considered new in the sense requested by criterion 1: they indicate the necessity of a novel term that emphasizes their use in contrast to using standard information like medical history or other non-genetic biomarkers (e.g. blood pressure).
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Molecular pathway-level mechanisms are intrinsically more stable and more robust than an individual gene.
Or are different molecular or pathway level effects of temperature buffered by other systems?
Chemicals displayed a broad spectrum of activity at the molecular and pathway levels.
Using 467 in vitro assays across 9 technologies, including high-throughput cell-free assays and cell-based assays in multiple human primary cells and cell lines, they investigated a broad spectrum of chemical activities at the molecular and pathway levels.
This study represents the first effort to extend the molecular characterizations towards pathway level descriptions across the family of cancers.
As LDH and pro-angiogenesis factors are regulated by the same HIF1- α-driven molecular pathway, high LDH levels are concomitantly present along with abnormal activation of the VEGF pathway (Harris, 2002).
Pathway analysis was performed in PathVisio 3.1.3 (http://www.pathvisio.org) to interpret and visualize the molecular changes on a pathway level.
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