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The fact that our experimental system selectively affects the development of CD8+ Tm cells without influencing the number and function of effectors generated have allowed us to identify key molecular events required for CD8+ Tm cell generation.
To confirm that those molecular events required for LFA-1-induced mRNA stabilization were also required for HuR translocation, immunofluorescent HuR localization analysis was performed on wild-type Jurkat or J.Vav1 cells adhered to immobilized rICAM-1.
However, further studies are required to uncover the critical molecular events required for promoting Oct4 binding and its potential role in enhancer activation.
Benzene is also a known leukemogen but the molecular events required for the development of benzene-induced leukemia occur over an 8- to 15-year latency period [ 20, 21].
In particular, studies of the 3T3-L1 celineine derived from mouse embryo fibroblasts [ 3] have been valuable for gaining insight into the ordered cascade of molecular events required for adipogenesis [ 4- 6].
The ability to consistently induce a leukaemic phenotype in all AE-expressing animals furthermore demonstrated that secondary molecular events, required for the onset of manifest disease, did take place within the time frame of the experiment.
Similar(50)
However, the complexity of temporal and spatial integration of these molecular events requires that they are studied in intact cells.
Transcriptional and post-translational molecular events are required for the consolidation of information into long-term memories and are thought to lead to the synaptic structural changes that maintain the memory [1], [2].
However, an understanding of the precise molecular events involved requires further research.
Putative AGC events required validation.
Some autoimmune events required treatment with steroids.
Related(20)
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