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This might be a problem for some molecular data types, but often data can be transformed to approximately achieve normality.
Furthermore, with an increasing number of subjects and molecular data types the comparison of the many tracks becomes complicated.
Second, GEMOT is applicable to a variety of molecular data types in addition to gene-expression data.
The rapid development of microarray technologies in recent years has led to the possibility of acquiring a large spectrum of different molecular data types.
It complements database developments by the NCI, DTP but with a particular emphasis on data queries and integration of different molecular data types.
The following molecular data types were evaluated: global gene expression, selected protein and phospho-protein expression, global miRNA expression, global DNA methylation, total number of somatic mutations, TP53 and PIK3CA somatic mutations, and global DNA copy-number aberrations.
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However molecular data regarding these types of tumors of the breast are lacking.
The molecular data on SCCmec type was also consistent with a community origin for these strains.
The present study on a dose-relationship of the CLIP2 marker is based on carefully assessed molecular data of CLIP2 typing according to Selmansberger et al. (20) and has used very reliable individual dose estimates (6, 35).
Geneious Basic has been designed to be an easy-to-use and flexible desktop software application framework for the organization and analysis of biological data, with a focus on molecular sequences and related data types.
Integrating data from different high-throughput measurement platforms (e.g. transcriptomic and proteomic) can be particularly useful to comprehensively detect disease-associated genes, and statistical approaches have been specifically developed to iteratively expand a molecular network using multiple data types (Hwang et al, 2005).
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