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While the folding of proteins has long eluded the mechanism behind protein substrate recognition, our studies show that molecular and data mining tools have improved much, putting a comprehension of proteolytic cleavage within reach.
YJ, GTYC and WBL performed the molecular and data analyses.
KS and MLVM performed the molecular and data analyses.
CQY participated in the study design, carried out the molecular and data analyses, and drafted the paper.
SQ participated in the tissue collection, performed the molecular and data analyses, and contributed to the drafting of the paper.
ED: participated in study design and coordination, molecular and data analysis, data interpretation and drafting of the manuscript.
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XJ and LJ supported the molecular studies and data analysis.
DB participated in molecular experiments and data analyses.
Xiaojun Yao carried out molecular modeling and data analysis.
MGD participated in the molecular studies and data acquisition.
Chen Jiao carried out molecular modeling and data analysis.
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