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The ETO moiety was shown to interact with the nuclear receptor co-repressor (N-CoR) complex, which includes mSin3A and the histone deacetylase, HDAC1.

In particular, analog 21l, which possesses a cyclopentyl oxime moiety, was shown to have excellent pharmacological effects on retinal vascular leakage in a diabetic mouse model.

However the presence of N-linked sugar moiety was shown to be unimportant for tumor suppressive activity but was critically important for its immunoregulative activity which demonstrates that different molecular mechanisms are involved in these two types of biological functional activities attributed to AFP.

The c RGDfK) moiety was shown to be essential for tumor-specific drug accumulation, as evidenced by the lack of free unconjugated Bchl-D uptake [ 44].

It was originally proposed that the 18 KDa form of FGF-2 was responsible for its autocrine and paracrine signalling effects, but subsequently a nuclear 24 KDa moiety was shown to be responsible for the epithelial to fibroblast conversion and for the spontaneous metastasis to lungs, but not for the angiogenic response.

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The corresponding modes for an imidazole moiety are shown in Figure 2 (C).

The corresponding feature of the ES symbol, sssN, in the tertiary amine (sssN) moiety, is shown in Figure 1(b).

The palmitoleyl moiety is shown as slate spheres.

2D structures of these compounds along with the common moiety are shown in Figure 3(b).

A visual representation of this moiety is shown in Supplemental Figure 4.

The C-EDTA moiety is shown as sticks, with carbon atoms colored cyan.

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