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Exact(6)
The 2,6-diaminopyridine moiety was identified as a key component to inhibit Aβ aggregation.
Moreover, an early step catalyzed by a PKS complex leading to a lactone moiety, was identified in the biosynthesis of the meroterpenoid pyripyropene (Itoh 2010).
A 4-subsituted benzoic acid moiety was identified as an advantageous replacement for the 3′3′-dimethylsuccinate moiety present in previously disclosed MIs that illuminates new aspects of the topography of the pharmacophore.
The aglycone moiety was identified as β-sitosterol from its H and APT spectra.
The fungal metabolite chaetocin bearing the epipolythiodioxopiperazine moiety was identified as a specific inhibitor of H3K9 methyltransferase SU VAR 3 9.
The sugar moiety was identified as a β-glycopyranosyl unit by analysis of the coupling pattern in H,H COSY and ROESY NMR spectra, as well as by correlations to six carbons in the H,C HSQC and HMBC spectra.
Similar(54)
Until that specific moiety is identified, the effect of the avidin-targeting moiety on the microparticle cannot be evaluated.
Several compounds with single-digit or even sub-nanomolar potency, suitable for further elaboration of the nitrile moiety, were identified.
A novel series of PAI-1 inhibitors containing an oxadiazolidinedione moiety were identified by high through-put screening.
Macrocyclic compounds bearing a 2-amino-6-arylpyrimidine moiety were identified as potent heat shock protein 90 (Hsp90) inhibitors by modification of 2-amino-6-aryltriazine derivative (CH5015765).
Through extensive SAR studies, analogs bearing free amino groups and alternatives to the parent (S -α-methyl benzyl moiety were identified.
Related(20)
clustering was identified
segment was identified
fraction was identified
section was identified
grouping was identified
aliquot was identified
consortium was identified
moiety was detected
percentage was identified
part was identified
proportion was identified
split was identified
substance was identified
component was identified
party was identified
moiety was found
moiety was proved
moiety was converted
moiety was deduced
moiety was introduced
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