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Exact(8)
A close proximity of two interacting moieties is a necessity for charge transfer to occur between them [16].
Thus, the choice of certain terminal moieties is a critical task in the design of new dendrimers as carriers of therapeutic molecules.
However, although a single aromatic group appears to aid binding, bisphenol A, which has two such moieties, is a less potent inhibitor.
Thus, the conjugation of a TLR7 agonist to phospholipid or PEG moieties is a promising strategy to expand the clinical uses of these agents for infectious, malignant, or atopic diseases.
The formation of free carbonyl moieties is a common indicator of oxidation processes in natural and synthetic macromolecules, and it can be used to evaluate the extent of degradation processes.
Hence, the discovery of efficacious MMP inhibitors without strong zinc-binding functional moieties is a very active field of research toward the generation of clinical treatments for those serious conditions.[ 16] Peptide bonds of the protein backbone represent the ubiquitous binding motif for small molecules to modulate a biological target.
Similar(52)
Edwards and Hayashi (1965) rather found that the linkage between the two rhamnose moieties is an α-1,2-glycosidic linkage, as determined by periodate oxidation and methylation.
Chemospecific and regiospecific modifications of natural products by methyl, prenyl, or C-glycosyl moieties are a challenging and cumbersome task in organic synthesis.
The gallate moiety is a key component of many functional phytochemicals.
The thiazole moiety is a significant heterocyclic unit in drug invention.
The aziridine scaffold moiety is a known mutagenic toxicophore and is present in rule base systems such as Derek Nexus.
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