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The photo-reversible [4πs+4πs] cycloaddition reaction of pendant anthracene moieties represents a convenient strategy to impart wavelength dependent properties into hydrogenated carboxylated nitrile butadiene rubber (HXNBR) networks.
Thus, MK with partially hydrogenated isoprenyl moieties represents a novel virulence factor and MenJ is a contextually essential enzyme and a potential drug target in pathogenic mycobacteria and other Gram-positive pathogens.
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The rigid bicyclic framework with its lipophilic side chains and its hydrophilic trione moiety represents a nature-derived lead structure that arranges the substituents (R1 to R4) into a defined topographical orientation.
Molecular docking displayed that α-methylene-γ-lactones moiety represents a key element for binding to the ATP pocket of both PI3Kα and mTOR, via hydrophobic interaction and hydrogen bonds.
It is noteworthy that a tetrazole moiety represents a bioisosteric replacement for a carboxylic acid group.
11 This approach is illustrated in Figure 1 where the dialkoxy-functionalized BT (O2BT) moiety represents a weaker electron-accepting, and more soluble moiety than the parent BT moiety, 12 while the 5,6-difluoro-2,1,3-benzothiadiazole (F2BT) system correspondingly represents a stronger electron-accepting unit.
Recently Klán and co-workers demonstrated that readily accessible S-phenacyl xanthates undergo photoinitiated homolytic scission of the C S bond in the primary step, opening their use as PPGs for alcohols in the presence of H-atom-donating solvents, where the xanthate moiety represents a photolabile linker.
The benzimidazole moiety represents an important pharmacophore and privileged structure in medicinal chemistry.
This was done because it was expected that this compound also had affinity toward the AChBP as the choline moiety represents an important pharmacophoric part for AChBP binding pocket.
Compounds containing a quinone moiety represent an important class of biologically active molecules that are widespread in nature, displaying anticancer, antibacterial, antimalarial, and fungicidal activities.
Figure 1 presents the structural moieties represented by the SMARTS notations, and Table 2 gives names of the drugs matched to these structural moieties.
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