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It has been found that inclusion of carbohydrate moieties in a drug may increase its bioavailability and decrease toxicity.
However, the simultaneous analysis of both functional moieties in a single assay format has not been described so far.
These compounds promise to serve as leads to identify hASBT recognition moieties in a prodrug approach to target hASBT to increase drug absorption.
The combination of two or more distinct pharmacophoric moieties in a single hybrid molecule represents the most usual way to build multitarget anti-Alzheimer drug candidates.
Selected peptides and hybrid peptides (combinations of peptide sequences with organic moieties in a single molecule) self-assemble to form pores, channels and tubules.
These host materials are designed to have good electron transporting characteristics with narrow band-gap by adding more phenyl moieties in a 4,4′-N,N′-dicarbazolebiphenyl (CBP) chemical structure.
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Conversely, increasing the spacing to 20 methylenes resulted in a semicrystalline material displaying dimerized acid moieties in an orthorhombic lattice.
Therefore, bPEI is modified with various non-ionic, non-toxic moieties in an effort to reduce its toxicity.
The aim of this study is to synthesize 3-isoxazolidone derivatives bearing known chelating moieties in an attempt to develop new bactericidal anti-Chlamydiaceae molecules.
Calculations showed that the two anthracene moieties in an open-state are parallel to each other, separated by a proper distance so that they are able to dimerize to close the gate without introducing much strain.
From the docking analysis, experimental inhibitory potency relationship of compounds 1 7 exhibited the fundamental role of α,β-unsaturated carbonyl moiety in ring "A".
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