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The sample_missingness module was run two times (with 10 and 2% of missing calls thresholds), and the snp_missingness module was run in between to minimize data loss.

To optimize computation speed, the duplicated_samples module was run independently of the others, and some script was run in parallel on the cluster.

The module was run in TFF mode using the AKTA crossflow system (GE Healthcare, Little Chalfort, UK) as well as a manually controlled peristaltic pump for permeate flow control.

The CLC module was run with default parameters (mismatch cost 2, insertion cost 3, deletion cost 3, length fraction 0.5, and similarity 0.8) using FASTQ files as read input and using FNA files as reference input.

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The instructions were all self-explanatory and the teacher's role, once the module was running, was more of a guider than a teacher.

The module was ran with the default settings except the maximal size change in heavy atoms allowed in MMPs identified (13 in this work).

A bad data detection module is run on a solution set to detect and eliminate bad measurements.

But as the front-end measurement module is run on the client's virtual machine, there is a risk of being tampered with, so you need to measure real-time monitoring front-end module integrity to ensure that the front-end measurement module of the returned data is authentic.

Finally, the critiquing module is run for each indication found in the prescription.

The graph is then directly executable: modules are run interactively in the graph, and results are accessible via generic text visualisation tools linked to the modules.

Before starting the simulations, the demographic and marital modules were run several years before the introduction of HIV/AIDS in the population.

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