Sentence examples for modulation of iron from inspiring English sources

Such investigations may encompass interventions such as the modulation of iron release and disposal during CPB.

Of note, neutrophils and myeloid cells can also synthesize minute amounts of hepcidin in response to infectious agents, thereby allowing the modulation of iron availability in an autocrine fashion at the infectious focus [ 115, 116].

Despite the progresses achieved in the last years, more studies on the role of iron in the parasite development and on modulation of iron metabolism in infected hosts are required before translation of this knowledge into effective treatments.

However, additional research is required to dissect the exact contribution of the different liver and spleen associated MYPS cell subsets (Ly6c+ and Ly6c− monocytes, resident and Ly6c+ monocyte-derived macrophages, granulocytes, and dendritic cells) in erythrophagocytosis or modulation of iron homeostasis and to Gal-3 or MIF production.

Whether the modulation of iron-related genes is part of a general UPR strategy aiming at maintaining cell viability and homeostasis or, instead, it represents a novel pathway to specifically control the expression of a subset of genes related to iron metabolism, remains the subject for further study.

These data make the modulation of brain iron metabolism an attractive therapeutic target not least because the concentration of Fe2+ in amyloid plaques is 1 m m, almost three times the normal level (Bush, 2003).

Previous work identified an increase in the quantity of cleaved transferrin fragments in the mucus of L. salmonis-infected Atlantic salmon, and the authors discussed the possibility of this being due to louse-mediated modulation of the iron sequestration role of transferrin [ 66].

To gain additional insight into the modulation of the iron-genes under scrutiny, we assessed the influence of varying doses of each UPR inducer on their transcript levels.

As zinc, copper, and iron are preferentially channeled through the MECs into the milk [ 9], this transcriptional modulation of ion transport systems probably reflects this process.

Future studies are required to define the precise biochemical pathway of iron modulation by PrP, and develop therapeutic strategies to prevent iron induced neuronal death in prion disorders.

To better understand the role of sea bass slc11a2 genes, in vivo and in vitro experimental models of iron modulation and infection were created.