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In which, the manipulation of iron pool leads to modulation of p53 target genes involved in the antioxidant response and apoptosis (Dongiovanni et al., 2010).
Objectives: The understanding of the role of iron metabolism during M. avium infections in mouse models may allow the design of new therapies based on the manipulation of iron stores.
Novel therapeutic possibilities include both the manipulation of iron status through intravenous iron therapy and, tantalisingly, hepcidin antagonists becoming available.
The influence of iron on HPV is demonstrated by the striking effects of experimental manipulation of iron levels in healthy humans.
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Based on the probable role of iron in KS pathogenesis, it is suggested that manipulations of iron load might interfere with tumour growth in patients with KS.
Since we observed that frataxin levels varied over at least a 2.5-fold range with manipulations of iron, we suggest that frataxin expression could potentially be increased significantly in patients by judicious management of iron status.
All the hallmarks of Violet's character — the implacable cruelty, the shrill self-pity, the wily manipulation and the will of iron — are present and accounted for in Ms. Parsons's superb performance.
In the future, regulation of iron metabolism through hepcidin manipulation could be carried out at two levels: locally to enhance host defence (through hepcidin synthesis induction), and systemically to prevent anaemia of inflammation (through hepcidin inhibition).
In the intrinsic magnetic manipulation technique, magnetic properties of iron-containing cells and biomolecules are harnessed to enable manipulation.
We also applied new approaches to generate iron-deficiency-tolerant rice lines, including the introduction of an engineered ferric-chelate reductase gene and manipulation of transcription factor genes regulating the iron deficiency response.
The inclusion of iron oxide paves the way for remote manipulation of polymer materials in three dimensions with a precision that is unachievable with traditional polymer materials, introducing the ability to generate organized constructs in 3D tissue space.
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CEO of Professional Science Editing for Scientists @ prosciediting.com