Sentence examples for modulating their functions from inspiring English sources

Kinases directly interact with and phosphorylate downstream substrates, thus modulating their functions.

Also, mutant p53 interacts with p63 and p73, thus modulating their functions.

Most likely, the PINK1 kinase exerts its neuroprotective effect by phosphorylating specific mitochondrial proteins and in turn modulating their functions.

Trx can exert its protective functions either directly as an antioxidant or indirectly by binding to signaling components and modulating their functions.

The function of a lncRNA may be mediated by the gene's RNA product which can bind to proteins or to other nucleic acids thereby modulating their functions.

Trx can exert its protective functions either directly as an antioxidant by reducing the ability of oxidized Trx peroxidase to scavenge ROS, such as H2O2, or indirectly by binding to signaling components and modulating their functions.

Therefore, fluvastatin-releasing hydrogels may be useful in bone tissue engineering applications, not only for triggering osteogenic differentiation of hMSCs, but also by modulating their function.

Given the broad distribution of circulating and tissue-specific galectins, understanding the relevance of lectin glycan interactions in shaping regulatory cell compartments will contribute to the design of novel therapeutic strategies aimed at modulating their function in a broad range of immunological disorders.

They serve as platforms for the localization and aggregation of molecular partners, modulating their function by clustering signaling partners in close proximity or, in some cases, by keeping them separated (see [25] [28] for reviews).

The class IIa HDACs shuttle between the nucleus and cytoplasm and precise regulation of their subcellular distribution plays a pivotal role in modulating their function, via post-translational modifications such as phosphorylation, and the formation of nucleocytoplasmic shuttling complexes [31], [47] [60].

Small synthetic lipophilic molecules can act as ligands, modulating their function.