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It is not surprising that these enzymes became the focus of intense research as therapeutic potential of modulating their activities became apparent.
AA can bind to biological proteins modulating their activities.
Chl can bind to biological proteins modulating their activities.
Additionally, other types of PTMs occurring on kinases as previously described play a role in modulating their activities, which are usually not accounted for in these studies.
Rho proteins, once activated, stimulate signalling in multiple pathways by binding to downstream effector proteins, modulating their activities and thereby regulating a range of cellular processes.
While stomatin and stomatin-like proteins are known to interact with various ion channels modulating their activities [19,22 25], only human stomatin has been shown to associate with the glucose transporter GLUT1 [26 30].
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PARP1 binds hnRNPs4,44,45, modulating their activity, to alter splicing decision4,45.
Traditional drug discovery starts by experimentally screening chemical libraries to find hit compounds that bind to protein targets, modulating their activity.
These potent vectors offer new opportunities for characterizing the identity and connectivity of single neurons within immense networks and modulating their activity via robust delivery of functional genetic tools.
Although the natural ligands of class C receptors bind to their extracellular N-terminal domains, the possibility of modulating their activity through ligands that bind to their helical bundle has been reported.
NOX2-mediated ROS inactivate cysteine cathepsines in the phagosome, thus modulating their activity.
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