Sentence examples for modulated by mutation from inspiring English sources

Translation efficiency is also targeted by PI3K signaling and modulated by mutation in tumor suppressors PTEN and TSC.

Of these two hypotheses, the gene cluster model seemed to most faithfully represent Ohno's postulate that the major mechanisms behind genomic evolution are gene duplication, modulated by mutation, insertion and deletion [ 1].

The nuclease activity can be modulated by mutation of the ATP-binding cleft of the helicase domain, and is inhibited by ATP or ADP, suggesting a modified role for the inactive helicase domain in the control of the nuclease activity.

The efficiency of transcription of the pac gene can be genetically modulated by mutation or removal of the regulatory region, mutations in the transcription initiation region, or by replacement of the pac promoter [ 9- 11].

The exonuclease activity is modulated by mutation of the helicase ATP-binding cleft and by ATP or ADP binding, suggesting a modified role for the helicase domain in the regulation of nuclease activity in these enzymes.

It has also been shown that the propensity of ApoAI to form fibrils is modulated by mutations and oxidation.

P450s may be especially prone to this type of change, since their catalytic mechanism involves large substrate-induced conformational shifts [ 40] that can be modulated by mutations distant from the active site [ 32, 37, 41].

Therefore, we propose the magnitude of the TM7−TM2 interaction as a property modulated by mutations at positions 7.53 and 7.60 that contributes to the final receptor phenotype, in combination with the TM7−HX8 conformational sampling.

However, the mechanism underlying the drug response modulated by EGFR mutation is still largely unknown.

This observation indicated that PAK1 expression is modulated by APCmin mutation and activated β-catenin signaling in the polyps.

We experimentally showed that the proportion of the low state cells after the diversification depended on the initial cell density and the AHL production rate, which is modulated by the mutation of luxI gene.