Sentence examples for altered by mutation from inspiring English sources

Genes involved in oxidative stress response and squamous differentiation pathways were found to be frequently altered by mutation or copy number alteration or up-/down- regulation in squamous cell lung cancer [27].

Protooncogenes can be altered by mutation or epigenetic modification, which converts them into oncogenes and leads to cell transformation.

The target gene itself can be altered by mutation or amplification, thus limiting the ability of the drug to inhibit activity of the kinase that remains active and drives aberrant signaling.

Such exons may have originated from old repeated sequences, with splicing sites altered by mutation, and gained functions with time, and eventually became more frequently spliced.

At the transition to the next generation, the mRNA abundance of each gene was altered by mutation following fi'(t+1) = fi(t) (1+kit), where kit was the normally distributed random variable.

Second, natural selection acts on the resulting phenotypes produced by this interaction, thus the response to selection and the long-term course of evolution depend on how variation in network properties can be altered by mutation and recombination.

The genotype of a cell can be altered by mutations.

Such promiscuous marker misexpression is a common observation in cancer where the GRN architecture is altered by mutations.

Kinetic parameters of biochemical systems can be altered by mutations resulting in perturbed activities and are subject to fluctuations due to variations in the environment (pH, temperature, ionic strength).

Although, it is postulated that asymmetric self-renewal by TSSCs must be ablated for them to become tumor precursors [9], [15], such mutated cells may still maintain markers associated with their previous capacity for asymmetric self-renewal, even after this TSSCs function is altered by mutations.

Uni-strand clusters 2 and flam are apparently not altered by mutations in cuff.