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Mammary branching is modulated by diverse factors, including members of the EGFR family (for review, see [ 37]).
Eukaryotes achieve this diversity by combining a small number of transcription factors whose activities are modulated by diverse sets of conditions [ 5].
Wnt signaling is modulated by diverse receptors and antagonists such as Frizzled, LRP, sFRP, and the Dickkopf (DKK) family members [ 6].
The stabilities of p63 proteins are modulated by diverse posttranslational modification, such as phosphorylation, ubiquitylation, SUMOylation, and ISGylation, in which various proteins are involved [ 26, 37– 37].
Virulence gene expression in most bacteria is modulated by diverse parameters, including pH, ion concentration, growth phase, population density and contact with the host.
Similar(55)
Further, neuronal oscillations are aptly represented by the EEG signals [50] and it is widely documented that large scale brain oscillations in various frequency bands is modulated by a diverse range of tasks in human cognition (see [51], [52], [53] for reviews).
It has been proposed that the function of microtubules is modulated by highly diverse posttranslational modifications of tubulin dimers [ 5].
Genetic studies in Drosophila suggest that the Hippo kinase cascade is modulated by a diverse array of upstream regulators (Boggiano and Fehon, 2012; Enderle and McNeill, 2013).
Microarray analyses provide a data-driven approach for judging which pathways serve as "hubs" that connect the diverse processes modulated by CR and aging, and this can lead to the construction of large gene interaction networks, with scope substantially greater than those generated by standard methods.
Given the large number of substrates, the diverse host functions modulated by these proteins and the possibility that translocation signals may be one of the parameters that control temporal translocation of these proteins, it is likely that previous screens have missed some substrates with undefined features.
This observation was likely to be attributed to the shared regulatory genes modulated by these stress-related miRNAs across diverse stress responses, indicating that the inferred cross-regulation of miRNAs might link plant responses to various stresses [ 4].
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