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Exact(5)

Results of the analysis on the level of gene expression differed from those on the protein level, indicating that cytokine/chemokines are modulated at both levels similar to what has been observed in other experimental paradigms [57].

Considering that a significant proportion of the differentially expressed genes are modulated at both time points, there were 870 differentially expressed transcripts in V. riparia and 187 in V. vinifera, with many modulated at both time points.

However, we required that genes be transcriptionally modulated at both early and late time points, thus hopefully minimizing the potential secondary downstream effects.

We considered genes transcriptionally regulated if they were modulated at both time points of 5-AzaC treatment compared to the untreated controls (overall 2-fold change and p-value < 0.05).

Additionally, we investigated the expression of a panel of catabolic genes, MMP-1, MMP-3 and MMP-13, which have been reported to be modulated at both the mRNA and protein levels by IL-1β in chondrocytes to [ 42].

Similar(55)

However, autophagy is a dynamic, multi-step process that can be modulated at several steps, both positively and negatively.

In the airway, CFTR plays an essential role in maintaining mucociliary clearance by regulating the airway surface liquid., A central aspect of this regulation involves control of Cl- secretion across polarized epithelial cells, which is modulated at the level of both CFTR channel activity and cell membrane abundance (reviewed in, ).

Proliferation of both HepG2 and Huh7 HCC cells was significantly decreased upon exposure to radiofrequency electromagnetic fields, which were modulated at HCC-specific modulation frequencies.

Both machineries were also modulated at the mRNA level upon DC activation with LPS (Figure 7A and B).

Note that VTA unit activity often increases during reward approach and reward acquisition, and that VTA unit activity can be both positively and negatively modulated at SPW-R events.

The helicity of linearly polarized pump beam was modulated at 50 kHz by a photoelastic modulator for lock-in detection.

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