Sentence examples for modified at both from inspiring English sources

Proteins modified at both sites form activity gradients with long plateaus that abruptly decay at successive locations along the path from the membrane to the nucleus.

However, the Limma models were modified at both the normalization and analysis stages.

We speculated that this was most likely to be a triply N-glycosylated form of the OPG TASK-1-E60 fragment that had been mOPG TASK-1-E60h its N- and C-terminal extensions during membrane insertion (cfragmente 3A).

We observed differential effects of the two doses of strontium ranelate: structure appeared to be modified at both 1 and 2 g/day, while symptoms required 2 g/day for significant amelioration.

Since phosphorylation of STAT3 on Ser727 appears to control its access to mitochondria, the significant levels of Tyr705-phosphorylated STAT3 that we observed in mitochondrial fractions is a likely indicator that the dominant species under these conditions is modified at both sites.

More complicated is the observed difference in activity between VA-1 and vancomycin (both modified at the glycosidic primary amine).

The advantage of this approach is that a targeting molecule is only modified at a single site, allowing both optical and PET labeling without increased steric demand, lowering the chances of compromising targeting efficiency.

We demonstrated that APT-2 can deacylate two unrelated proteins like H-Ras, which is modified at its C-terminus by both acylation and prenylation and GAP-43, which is acylated on N-terminal cysteines 3 and 4.

Moreover, both isoforms are modified at the post-translational level by oxygen-dependent PHD and FIH-1 enzymes [ 18].

In both cases, temperature was modified at a ratio of 0.5 °C/day.

Expression levels of protein markers of axonal and synaptic vulnerability were also significantly modified at pre/early- symptomatic stages of disease progression in both mouse models of NCL.