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The insulin receptor is a modular protein containing several specific functional domains.
BAG3 is a modular protein containing WW, PXXP, and BAG domains, which can interact with different partners.
Collectively, pLbaR_38 is a highly modular protein containing eukaryotic-like domains and regions similar to proteins encoded in other intracellular bacterial genomes.
STIP1 is a modular protein containing several tetratricopeptide (TRP) repeat domains and aspartate-proline (DP) reach domains (Taipale et al., 2010).
p53 is a modular protein containing an N-terminal transactivation domain, followed by a proline-rich region, a central DNA-binding domain (p53C), a tetramerization domain, and a C terminus.
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Our results demonstrate that tandem modular proteins containing TNfn3 can be readily photochemically crosslinked into elastic hydrogels, whose Young's modulus can be tuned by the concentration of the tandem modular protein solution.
HKs and RRs are modular proteins containing homologous and heterologous domains [ 2, 3].
Cell signaling pathways rely heavily on modular proteins containing protein protein interaction domains to sense, transmit and process signals that regulate cellular functions (1).
Three different types of polyketide synthases (PKSs) produce carbonyl polymers by condensing activated acyls (typically acetyl-CoA and malonyl-CoA) (Shen 2003; Cummings et al. 2014): Type I PKSs are large, highly modular proteins containing domains which catalyze biosynthesis steps, whereas type II PKSs are complexes of multiple individual proteins with dedicated functions.
Several bacterial expression vectors have been constructed to produce modular proteins containing from the N- to the C-terminus: the FLAG epitope, a cleavage site for a protease, a PTD, human ubiquitin or SUMO-1, and either GFP or the HA epitope.
These modular proteins contain flexible linkers of various lengths, which enable changes in the spatial distribution of the globular domains (architecture) that harbor their essential biochemical functions.
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