Sentence examples for modifying the intracellular from inspiring English sources

The cysteine peptidase inhibitor was capable of modifying the intracellular localization of cruzipain and induced its accumulation in peripheral dilations of Golgi cistern, these abnormalities were followed by distention of endoplasmatic reticulum and nuclear membranes [46].

As well as modifying the intracellular distribution of lysosomal β-hexosaminidase [11], observations indicate that CCMA also causes a BFA-independent appearance of lysosomal β-hexosaminidase in the culture medium without accompanying cell damage as assessed by extracellular LDH levels (Chantret, I. and Moore, S. unpublished observations).

Based on these studies, we hypothesized that modifying the intracellular localization of AhR through changes in cell density should affect the membrane distribution of Cav-1.

This antibody-driven immunoreactivity loss was reduced by modifying the intracellular Ca2+ transients and inhibiting the Ca2+-dependent protease calpain (Table  1).

A change at the binding site may affect the union between the ligand and its receptor, modifying the intracellular signaling events, thereby influencing the expected physiologic response.

High-energy or fat-enriched diets may work, not only through an impaired ability of insulin to activate the peripheral PI 3-kinase pathway, but also by negatively modifying the intracellular insulin signaling in the hypothalamus (27).

Progress in understanding the molecular pathogenesis of the disease, vaccine engineering and postgenomic approaches aimed at the discovery of new pathways used by this pathogen to modify the intracellular environment may lead to new preventive interventions.

The presence of Oxa was found to modify the intracellular metabolic profile of FU.

The presence of Oxa itself does not modify the intracellular concentration of reduced folates.

The presence of oxaliplatin itself did not modify the intracellular concentration of total reduced folates.

As expected, p21 is undetectable in HCT116 p21-/ cells, and DOX treatment does not modify the intracellular levels of this protein.