Sentence examples for modifying the acetylation from inspiring English sources

TG2 in macrophages has been shown to require the metastatic tumor antigen 1 (MTa1), a ubiquitously expressed chromatin modifier that regulates transcription of its targets by modifying the acetylation status of the target chromatin and the consequent co-factor accessibility to the target DNA, both for its basal and lipopolysaccharide-induced expression [ 24].

Despite its strong correlation with the metastatic potential of cancer cells, MTA1 can also regulate crucial cellular pathways by modifying the acetylation status.

Global regulation of transcription initiation may be achieved by modifying the acetylation state of these origins.

At week 6 mice were started on a 2-week behavioral test battery, and tissues were collected at the beginning of week 9. Measurements of α-tubulin acetylation were used to determine the efficacy of the treatment in modifying the acetylation state of α-tubulin at the Lys40 residue.

HDACs are proteins that regulate transcription by acetylating N-terminal tails of histone proteins and modulating facultative heterochromatin (Sleiman et al, 2009); alternatively or in concert they act by directly modifying the acetylation states of transcription factors or coactivators to recruit the basal transcriptional machinery (Ryu et al, 2003).

Sirt proteins modify the acetylation level of histones and proteins (Verdin et al. 2010).

Several HATs and HDACs can modify the acetylation of K382 on p53 (Sakaguchi et al., 1998).

Among them, histone deacetylase inhibitors (HDACIs) modify the acetylation state of histone tails and induce cell cycle arrest at both G1 and G2 phases.

The specificity of HATs and HDACs for histones is not high, and they are known to modify the acetylation status of other proteins, such as nuclear factor-κB, p53 and STAT proteins, thus affecting their stability and functions.

We further explored whether the lncRNA upregulated OS9 expression by modifying the H3K27 acetylation level of OS9 gene promoter.

Most evidence to date on the role of central epigenetic processes in alcoholism has been collected from studies focusing on histone acetylation, often by modifying the activities of the enzymes that add acetyl groups (i.e., histone acetyl transferases [HATs]) or remove acetyl groups (i.e., histone deacetylases [HDACs]).