Sentence examples for modulating the acetylation from inspiring English sources

Here, we report data in support of the notion that bacteria can control gene expression by modulating the acetylation state of transcription factors (TFs).

Deprotection of genomic DNA regions can be triggered by modulating the acetylation of histone octamers.

The nuclear HS can also regulate gene expression by modulating the acetylation status of histone proteins.

We propose that changes in HDAC6 indirectly influence whether or not tau is degraded by modulating the acetylation state of Hsp90.

Deployment of H2A.Z splice variants with altered numbers of acetylatable K residues would seem less dynamic than simply modulating the acetylation status of a fixed number of K-residues.

49 Moreover, the demethylase Jarid1a is recruited with CLOCK/BMAL1 to circadian gene promoters and is involved in modulating the acetylation of histone H3 by inhibiting HDAC1, and subsequently enhancing transcription of the clock complex.

Through deacetylating acetylated lysine 40 in α-tubulin, Hdac6 modulates the acetylation of microtubules (Hubbert et al., 2002).

Chemicals that modulate the acetylation of nuclear proteins have proved instrumental in experimental models of several human diseases.

HDACs can also modulate the acetylation state and activity of major transcription factors [10].

sirtuins) [6], are conserved in all domains of life, and together, GNATs and sirtuins modulate the acetylation state of proteins involved in diverse cellular processes.

While HDAC activity is generally associated with transcriptional repression, through the deacetylation of histones, HDACs may also modulate the acetylation state of major transcription factors, and thus have complex effects on gene regulation.