Sentence examples for modifier genes involved from inspiring English sources

These data suggest that modifier genes involved in the regulation of TGF-β1 expression act in combination with a single functional copy of endoglin in the development of HHT.

In general, our knowledge of modifier genes involved in mitochondrial disorders has increased substantially in the past decade.

Identifying important modifier genes involved in the pathogenesis of cardiac hypertrophy might lead to the development of new therapeutic strategies.

In a similar C. elegans screen for α-synuclein aggregation, genome-wide RNAi screening identified modifier genes involved in protein degradation, vesicle trafficking, lipid metabolism and RNA metabolism.

As discussed in the next part, both the MLL2 and the UTX gene have been reported as important histone modifier genes involved in cancer pathogenesis.

Cardiac hypertrophy is associated with many forms of heart disease, and identifying important modifier genes involved in the pathogenesis of cardiac hypertrophy could lead to the development of new therapeutic strategies.

To the best of our knowledge, this is the first study showing deviations from HWE and selection involving a modifier gene involved in a Mendelian disorder.

In order to negate the first possibility we compared our modifiers with genes involved in protein homeostasis (Silva et al., 2011) as well as the ERAD network (Christianson et al., 2012).

Modules that were positively correlated with HD in the caudate nucleus network were, amongst others, enriched for transcriptional regulators, chromatin modifiers and genes involved in mRNA processing (modules CNpos1 and CNpos2, Table  3).

Several studies [ 5- 7] have shown that the RQH depends crucially on the linkage between the modifier and the genes involved in host-parasite interactions.

Untested genes involved in modifier-enriched processes can be prioritized in future screens to confirm these trends and elucidate their mechanisms.