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A change in the shape of the lower jaw can impair the natural occlusion and leads to an atypical or modified position of the temporomandibular joint.
The mathematical model indicates that structural change will lead to the outward variation of the natural frequency, which is essentially related to the change of the squared mode shape values between the original position and the modified position of the moving component.
On the basis of the DSP reaction specificity, the cross-linking modified position of the A chain should be the N terminus, which is the only possible cross-linked site.
Again, doubly charged anion of the modified B chain carrying one reduced dead-end tag is observed m/ z 1742.0, further confirming that the sole modified position of the native insulin was on its B chain.
To determine the modified position of the E2 B domain in these two complexes, the cryoEM density distributions were modified by setting to zero all density that was within 3 Å of all atoms in E1 and of all atoms in the A, C and D domains of E2.
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Modifications in SHAP-C: (1) downsized objects, (2) slightly modified positioning of a few objects on the form-board, and (3) the assessor timed the tasks and not the participant.
This observation suggested biological functions of modified positioned nucleosomes in controlling gene activities.
Table S1 in Additional file 1 listed the numbers of modified positioned nucleosomes for each histone modification.
These observations suggest an epigenetic mechanism of modified positioned nucleosomes in establishing and maintaining functionally important regulatory regions in the human genome.
As observed previously [ 17], the kinetic signature for 5mC is distinct from the background, but the magnitudes of the IPD ratios are small, translating to relatively high sequencing coverage for detection of the modified positions with high confidence.
ts−1, F i. te] indicating the modified ending position of F i, and r+1 indicating the modified starting position of F i +1 in the transcript.
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