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The full length CrSPI-1 with this modified role of CrSPI-1-D1 as a thrombin modulator, might play a central role in regulating not only hemostasis but also inflammation, and may provide a close link between these processes and how they might co-evolve in the biological system.
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In a similar sense, our diet score broadly captures several dietary characteristics; therefore, neither the clinical trials data nor those from our analyses allow us to speculate on the effect modifying roles of individual dietary components.
We conducted a hospital-based case-control study to further investigate the overall association between aspirin use and lung cancer risk, and to add to the limited body of evidence on the potential effect modifying roles of tumor histology and cigarette smoking on the chemopreventive role of aspirin in lung tumorigenesis.
In addition, we investigated the potential modifying role of PMIND (dichotomized at the third quartile) on PMTRA and vice versa.
However, few of previous laboratory or epidemiological studies tackled the potential modifying role of environmental factors on severity of infection, or mortality risks associated with influenza.
Further studies are needed to clarify the role of menarcheal age on cardiovascular outcomes and to investigate the potential modifying role of smoking.
Therefore, although the number of studies is limited, existing evidence is consistent with a potential modifying role of oxidant defence in PM2.5 induced cardiorespiratory morbidity.
Therefore, further evaluation of the potential modifying role of oxidant defence in PM2.5-induced health effects is required, particularly for chronic outcomes.
Only one [ 79] of the three [ 79, 91, 93] studies to examine the potential modifying role of radiation therapy found evidence that risk of a second breast cancer was higher in those who did not receive radiation.
The high prevalence of viral hepatitis in this target population also allows for a meaningful evaluation of the potential modifying role of viral hepatitis on the diabetes HCC association.
However, an appropriately designed nested case-control study within a whole cohort is universally recognised to yield valid findings, and we have conducted such a study to examine the potential modifying role of viral hepatitis in the diabetes HCC association.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com