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Genetically modified animals were created about 30 years ago, and are considered good models of human diseases.

Genetically modified animals were first created in the 1970s 1980s, and are considered good models of human diseases.

All the genetically modified animals were tested and compared with their control (wildtype or double heterozygote) littermates.

For assessing epidermal differentiation, mouse skin isolated from wild-type and genetically modified animals were frozen in OCT (Tissue-Tek, Sakura Finetek USA, Torrance, CA, USA).

Genetically modified animals were excluded as the mutations used to induce steatosis (leptin deficiency or leptin receptor dysfunction) are not prevalent in humans, and the pathophysiology of hepatic steatosis in these animals does not mimic NAFLD in humans [ 27, 28].

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A menagerie of other genetically modified animals is in the works, promising what biotech backers say will be advantages like cheaper and more nutritious food.

To the Editor: What is especially troubling about the Food and Drug Administration's decision to consider commercializing genetically modified animals is that consumers currently have no way of knowing which products sold in stores are, or contain, genetically modified organisms.

Scientists' successful development of a novel and efficient method for creating genetically modified animals is unlikely to be welcomed by those who are unthinkingly opposed to what is often described as an unnatural interference with the human food chain.

b Genetically modified animals are always larger than ordinary animals.

During the last decade genetically modified animals are increasingly used to study the development of obstructive nephropathy.

As wide inter-individual variability is unavoidable, sufficient numbers of animals, a cautious comparison with both study and historical controls, and the possible use of inbred or genetically modified animals are to be considered.

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