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It describes an autocatalytic, trimolecular reaction that, for instance, occurs in post-translational modifications of signaling proteins.
In this process, secondary modifications of signaling proteins may be crucial for the biological activity of these proteins.
Post-translational modifications of signaling proteins, such as phosphorylation and ubiquitination, are important for the regulation of gene expression in response to stress.
The encoding of the input information into post-translational modifications of signaling molecules and the subsequent decoding into defined outputs is a highly nonlinear process.
Since the results highlighted some modifications of signaling molecules, the enzymes of the metabolism could be fine-tuned specifically in each genotype to adjust the concentration of metabolites.
Are the redox modifications of signaling molecules (FoxOs, APE1/Ref-1, Nrf2, ATM, HIFs, p38 and p53) involved in the regulation stem cell self-renewal and differentiation?
Similar(54)
Aberrant O-GlcNAc modification of signaling proteins, metabolic enzymes, and transcriptional and epigenetic regulators has been implicated in cancer.
The unveiling point mutations within the kinase domain, gene amplification or overexpression, or modification of signaling pathway have been implicated in drug resistance.
Concerning the QLT0267-related 3-fold, unexpected increase in ILK activity in 3D UTScell culturestures, it can be speculated that such effects result from transcriptional and posttranscriptional modification of signaling pathways as well as from changes in protein-protein interactions induced by cell-matrix interactions in the 3D microenvironment.
None of the primary cultures or lung cancer cell lines revealed such a drastic modification of signaling as a function of transformation.
Previous works and ours suggest that the accumulation of esterified cholesterol may lead to a modification of signaling pathways associated with proliferation and migration in tumors.
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