Sentence examples for modification of signaling from inspiring English sources
Federici, M. et al. Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells.
Aberrant O-GlcNAc modification of signaling proteins, metabolic enzymes, and transcriptional and epigenetic regulators has been implicated in cancer.
The unveiling point mutations within the kinase domain, gene amplification or overexpression, or modification of signaling pathway have been implicated in drug resistance.
Concerning the QLT0267-related 3-fold, unexpected increase in ILK activity in 3D UTScell culturestures, it can be speculated that such effects result from transcriptional and posttranscriptional modification of signaling pathways as well as from changes in protein-protein interactions induced by cell-matrix interactions in the 3D microenvironment.
None of the primary cultures or lung cancer cell lines revealed such a drastic modification of signaling as a function of transformation.
Previous works and ours suggest that the accumulation of esterified cholesterol may lead to a modification of signaling pathways associated with proliferation and migration in tumors.
For example, covalent modification of signalling proteins allows for the accumulation of a signal over time.
Chaperones also participate in the post-translational modification of signalling molecules, the assembly and disassembly of transcriptional complexes and the modulation of immunogenic proteins (Bagatell, 2004).
In future applications, HATRIC chemistry should enable the analysis of post-translational modifications of signaling competent receptors and, given the drastically increased sensitivity of the HATRIC technology, applications using rare biological or clinical specimens, opening up new avenues for biomedical research.
In this process, secondary modifications of signaling proteins may be crucial for the biological activity of these proteins.
It describes an autocatalytic, trimolecular reaction that, for instance, occurs in post-translational modifications of signaling proteins.
