Sentence examples for modifications constitute the from inspiring English sources

Instead, our results indicate that post-translational histone modifications constitute the mechanism underlying MDR1 deregulation in PCa.

While these modifications constitute the biochemical basis for epigenetics, not necessarily always, epigenetics is addressed when they are investigated.

In conclusion, unaltered epigenetic regulation pathways like DNA methylation and posttranslational chromatin modifications constitute the basis of a healthy cardiovascular system.

The process of joint morphogenesis during development and its evolutionary modifications constitute the basis for the diverse locomotive behaviors of animals.

At the same time, the production of snoRNPs and rRNA modifications constitute the core function of Myc, as 48% of its mostly highly controlled target genes are dedicated to this task.

In fact, reversible lysine acetylation and serine phosphorylation of the histone tails at specific positions are known to modulate the structure of chromatin, and the histone tail-mediated internucleosomal attraction and control of the chromatin conformation through site-specific posttranslational modifications constitute the basis of the histone code hypothesis.

The final set of modifications constituted the fitting of new injectors and Automatic Warning System (AWS) equipment in 1957 and 1959 respectively.

16 Since disease modification constitutes the most important therapeutic intervention in RA, it was the objective of this EULAR Task Force to find a consensus on recommendations for the management of RA with synthetic and biological DMARDs.

A popular hypothesis is that such oxidized cytosine modifications constitute part of the pathways that lead to active DNA demethylation.

Although transcriptional deregulation has a central role in a large array of cancers including acute leukaemia, it is evident that epigenetic machineries including DNA methylation and post-translational histone modifications constitute integral functions of the oncogenic transcriptional complexes in mediating the aberrant transcriptional programmes (Cheung and So, 2011).

Two chemical modifications may be regarded as starting points for this field, namely, 2′-fluoro (2′-F) substitutions and phosphorothioate chemistry, since ONs with these modifications constitute versatile, synthetic analogs of the naturally occurring counterparts (Fig. 1).