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Histone modifications are key components of chromatin packaging but whether they constitute a 'code' has been contested.
A combination of imaging approaches and biochemical methods to probe genome architecture and chromatin structure suggest that the spatial organization of the genome and features of chromatin, including sequence properties, higher order chromatin structure and histone modifications, are key determinants of translocation formation.
Chromatin modifications are key for distinguishing regulatory elements [ 7, 17].
In general, protein modifications are key regulators of protein function, and several modifications have been reported to affect the function of nuclear transport factors.
Although lifestyle and diet modifications are key in NAFLD treatment, the development of new pharmacological therapies is crucial for patients who are unresponsive to first-line therapy.
Ever increasing evidence supports the view that histone modifications are key epigenetic marks that can influence gene expression during development and pathogenesis.
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These modifications were key factors for the establishment and development of an arthropod community composed by xylovores (Bostrichidae, Scolytinae, Buprestidae, Lyctidae and Cerambycidae) and natural enemies (Histeridae, Cleridae and Hymenoptera).
Understanding such modifications is key to understanding site-specific protein function.
Thus, characterizing global nucleosome positions and their chemical and compositional modifications is key to unravelling the mechanism of transcriptional regulation.
The ability to identify specific proteins that are most susceptible to oxidative modifications is key to the development of methods for early diagnosis, assessment of new potential therapies and understanding the overall disease mechanisms.
Understanding what is being measured, what influences it and exploring effect modification are keys to our approach [ 2].
Related(15)
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