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Intriguingly, some of these histone modifications are dependent on p53.
These histone-remodeling modifications are dependent on repression of RORC by H3K27me3 in the rorc locus, as mediated by T-bet and STAT4 [ 105].
The heterochromatin specific histone modifications are dependent on both the RNA pol II complex as well as small RNA silencing machinery components.
First, it is essential that the modifications are dependent on the genetic context (the new genetic modifications will interact with other genes in the genome, specifically mouse genes).
These modifications are dependent on the genetic background of mice, the type of helminth, and the time-course of the initial helminthic infection, which is crucial to the resulting immune response to Plasmodium.
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DNA methylation and histone modification are dependent on one another in regulating gene expression.
The effect of backbone modification was dependent upon the positions where these two aza-β3 residues were located, although the sequence of amino acid side groups remained the same in all compounds.
The new cationic modification is dependent upon incorporation of alkylamine groups on exposed hydroxyls.
This modification was dependent upon PAD4 because PAD4 KO mice exhibited no staining for citrullinated histone H4.
This modification was dependent on Cys431, His433 and Glu444, suggesting that His433 and Glu444 indeed modulate the reactivity of Cys431 and constitute a catalytic triad.
Similar to PCNA, the 9 1 1 complex is ubiquitinated; however, published data disagree on whether this modification is dependent on Rad6 and if Lys197 or Lys164 of Rad17 is the major acceptor site for ubiquitin.
More suggestions(14)
modifications are necessary
modifications are successful
modifications are irreversible
modifications are numerous
modifications are equal
modifications are illegal
modifications are systematic
modifications are reversible
modifications are similar
modifications are common
modifications are likely
modifications are due
modifications are available
modifications are key
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