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Permanent modifications are increasingly slowing, while September saw the sixth straight month of double-digit decreases in active trial modifications.
As highlighted above, changes in epigenetic modifications are increasingly being associated with prostate cancer.
Histone modifications are increasingly being used as biomarkers of cancer prognosis and survival.
Histone modifications are increasingly being used as biomarkers of cancer prognosis [ 1].
Furthermore, epigenetic changes including histone modifications are increasingly being linked with gene dysregulation and cellular responses induced by air pollutants, including ambient PM [ 8].
Environ Health Perspect 122 946 954; http://dx.doi.org/10.1289/ehp.1306674 DNA 5-methylcytosine (5-mC) modifications are increasingly recognized as a key process in the pathogenesis of complex disorders, including cancer, diabetes, and cardiovascular disease (Feinberg 2010; Ordovas and Smith 2010).
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The molecular mechanisms that underlie the epigenetic modifications of phenotype are increasingly well understood.
Histone modifications in tumorigenesis are increasingly recognized as important epigenetic factors leading to cancer.
In particular, enzymes catalyzing the covalent posttranslational modifications of histones are increasingly seen as critical regulators of transcription and the assembly of chromatin into various functional domains (Henikoff and Shilatifard, 2011; Badeaux and Shi, 2013).
Even for relatively simple biological systems such as prokaryotes, post-translational modification (PTM) events are increasingly being recognized as important, but are poorly characterized with regard to sites or function.
Hence, the screening for various crystal modifications has been increasingly emphasized in pharmaceutical industry as it provides valuable knowledge necessary for further development of the drug formulation [3 5].
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