Sentence examples for modifications and subcellular from inspiring English sources

CDK activity is regulated through posttranslational modifications and subcellular translocations of specific CDK inhibitors (CDKIs), which are organized in two families, INK4 and Cip/Kip.

6, 7 Due to differences in structure, posttranslational modifications and subcellular localization, the small GTPase families fulfill different functions within the cell.

hiMAC is compatible with cell types from any species and allows for statistically powerful, unbiased, simultaneous analysis of protein interactions, modifications and subcellular localization at all cell cycle stages within a single sample.

RBPs act on many kinds of RNA, such as ribosomal RNA (rRNA), transfer RNA (tRNA), small interfering RNA and microRNA, particularly at different stages of the messenger RNA (mRNA) life-cycle from splicing, polyadenylation, various modifications and subcellular localization to translation [ 1].

Here we will briefly recall the main features of the structural organization of TJs at the BBB and will focus on transcriptional regulation, post-translational modifications and subcellular localization of TJ proteins and their consequences for BBB integrity with exposure to various environmental stimuli and during CNS disorders.

Function of p53 is regulated by several mechanisms, acting not only at the transcriptional and translational level, but also on stability, post-translational modification, and subcellular localisation of p53.

TFE3 post-translational modifications and its subcellular localization could be an important readout for the analysis of FLCN function and the function of the FLCN/FNIP1/FNIP2/AMPK complex.

Such functional diversity of GAPDH has been closely linked to its oligomerization status, post-translational modifications, and the subcellular localization of the enzyme (Tristan et al, 2011).

With the annotation of post-translational modifications, conformational changes and subcellular locations, the number of variant instances of a physical entity can be large.

TGHQ reportedly modulates 12- O-tetradecanoyl phorbol 13-acetate responsive element and nuclear factor-kappaB-binding activity in an ROS-dependent fashion (54) and exhibits other ROS-inducible events such as posttranslational modification of Bcl-2 and subcellular localization of Bax, culminating in the release of cytochrome c and caspase activation (55).

Because of its importance, p53 expression is regulated by a variety of means, such as transcriptional and translational control, alternative splicing, posttranslational modifications and regulation of subcellular localization.