The cytoskeletal disorganization was accompanied by altered patterns of serine and tyrosine phosphorylation as well as changed expression and subcellular localization of integral signaling intermediates APC and PKCβII.
The advantage of using GFP variants to label neurons is the ability to follow dynamic changes in cellular and subcellular compartments.
This physiologically-based, multi-scale computational model of skeletal muscle cellular metabolism and energetics can simulate dynamic metabolic changes in cellular and subcellular compartments and provide quantitative analysis of the mechanisms of metabolic regulation during physiological stresses (e.g., reduced blood flow and oxygen supply to mitochondria associated with muscle ischemia).
Since the cytoplasm is difficult to distinguish from the basolateral membrane in wing discs, and the section will include a large fraction composed of the nucleus, an additional method was used to help clarify changes in levels and subcellular location of proteins (Figure 3).
AFM can be used to image and track changes in cellular and subcellular morphology.
Complex and sex-specific changes in levels and subcellular distributions of these proteins occurred in response to stress and to fluoxetine [ 58, 59].
Future studies may clarify potential contributions of local conduction changes, and cellular and subcellular mechanisms of alternans, to the increased AF susceptibility.
Further studies in this model are warranted, to clarify potential contributions of local conduction changes, and cellular and subcellular mechanisms of alternans, to the increased susceptibility to AF.
To address this issue we investigated cell cycle-dependent changes in expression and subcellular distribution of the muscle FBPase isozyme in human squamous cell lung cancer (SCC), in the mouse SCC cell line (KLN-205) and in mouse cardiomyocytes (the HL-1 cell line).
Serpins with the capacity to defend the main cellular export/import routes against uncontrolled endogenous and/or foreign proteolytic activity represent an ancient trait in eukaryotes that has been maintained continuously in metazoans though subtle changes affecting function and subcellular location have evolved.
