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There are several reports of stress-induced histone tail modifications and altered stress resistance in mutants lacking histone-modifying enzymes.
Therefore, post-translational modifications, and altered synaptic protein synthesis, are likely to mediate many of the effects of sAPPα on LTP [ 17, 77, 78].
A range of chromatin modifications suppress their transcription, including histone modifications and altered chromatin packing.
Associations between a variety of posttranslational protein modifications and altered biological functions of proteins are becoming increasingly evident.
Indeed, a great number of tumor specific peptides have been identified and post-translational modifications and altered glycosylation in tumor cells shown to lead to generation of new tumor epitopes.
Certain properties of the mutated forms of Aβ such as posttranslational modifications and altered propensity to oligomerize/aggregate, could offer an explanation for the limited formation of structurally ordered Aβ fibrils in Arctic AD patients [ 41], whereas the underlying reason in the PS1Δ9 AD patients is even less clear, because the cotton wool plaques in such brains contain wild-type Aβ only.
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In contrast, phenolic compounds might reduce the quality of sunflower proteins by inhibiting digestibility, causing undesirable browning and structural modifications, and altering protein functional properties and behavior in various food matrixes.
COME to Wimbledon across the decades and change becomes a way of life, a powerful study of athletic modification and altered moods, all seemingly emanating from the rolling of a million rain clouds.
The introduction of oilseed rape in commercial agriculture raises concerns about potential adverse agronomic and environmental effects linked to both the genetic modification and altered agricultural practice.
Qualitative adipose tissue modification and altered adipose tissue distribution are key features in determining metabolic abnormalities in these subjects.
For example, aging modifies the structure-function relationship of the genome through accumulation of mutations, changing epigenetic profiles (both changes in DNA methylation patterns and histone modification) and altered telomere dynamics [ 5, 6].
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