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If endocrine mediators are responsible, pharmacologic modification of serum hormone levels may alter sepsis mortality.
After modification of serum protein with 0.2 mM Hcy-thiolactone, the protein thiol content increased to 1.18 from a reference value of 1.0 in untreated serum protein.
In the study reported here, we evaluated the effect modification of serum bilirubin and coffee intake on the association between GGT and glycated hemoglobin (HbA1c) in Japanese men and women.
Glycated albumin and fructosamine reflect the modification of serum proteins by glucose and are markers of endogenous glucose exposure over the prior 2 to 4 weeks, i.e., extending beyond the half-life of albumin and some other serum proteins.
An abrupt modification of serum osmolality, usually due to the rapid correction of hyponatremia and sometimes to that of hypernatremia [ 6, 7], can induce osmotic demyelination of regions of white and grey matter apposition, such as the pons varolii and some symmetrical cerebral and cerebellar areas.
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Children were excluded according to the same criteria used in the previous paediatric Phase Ib study [21], except for the slight modifications of serum alanine aminotransferase (ALT) of ≥45 IU/L and absolute lymphocyte counts (ALC) for one-year olds of <4.0×103/mm3, for two-year olds of <3.0×103/mm3, and for three-year olds of <2.0×103/mm3.
Expand the serum protein adductome to encompass the totality of modifications of serum proteins and identify adducts on tissue proteins.
Modifications of serum POP levels have been related to weight changes in the general population (Lim et al. 2011; Wolff et al. 2005a) or in obese individuals (Chevrier et al. 2000).
Detection of modified tryptic peptides with albumin sequences in the sample of patient's serum indicates that those amino acyl adducts came from serum albumin, although modification of other serum proteins is likely.
Also, periodate has been used in the modification of human serum transferrin by conjugation to an oligosaccharide [4].
The recognition elements were prepared by chemical modification of bovine serum albumin-BTX-2 conjugates (BTX-2-BSA) with the GGNRs.
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