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Adjustment of serum LPS activity with HDL concentrations strengthened the correlation with serum triglyceride concentration [ln LPS-to-HDL ratio) vs. ln(triglycerides), r = 0.68, P < 0.001].
However, after further adjustment of serum creatinine level, only PAP remained associated with any diabetic retinopathy (1.28 [1.07–1.54], P = 0.008) or vision-threatening diabetic retinopathy (1.51 [1.10–2.08], P = 0.01).
The antibodies used in the sandwich immunoassay were selected to target only the free form of NGAL, not NGAL in the homodimeric form or heterodimeric complexes with matrix metallopeptidase 9. Adjustment of serum creatinine and plasma NGAL was conducted as described previously [ 27, 28].
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After adjustment of the serum concentrations of YKL-40 for these two variables, serum YKL-40 was found to be significantly associated with SNPs in the CHI3L1 gene.
The analyses included mutual adjustment of the serum micronutrients.
Calculations to convert results to RBC folate concentrations require the addition and adjustment of a serum folate value for the Bio-Rad MA measurement procedure differences.
With adjustment of both serum bilirubin and ferritin values, the OR of HO-1 effect was reduced further to 1.71 and became nonsignificant (95% CI 0.75 3.90, P = 0.203) (Table 3).
We also analyzed the effect of adjustment for serum albumin or total serum protein concentration on the association of fructosamine and glycated albumin with mortality.
In contrast, serum ALT, a liver-specific enzyme, was not positively associated with blood lead irrespective of adjustment for serum GGT or with urinary cadmium after adjustment for serum GGT.
As might be expected, since the expression of glycated albumin is a ratio of glycated albumin to total serum albumin, there was a greater influence of adjustment for serum albumin or total protein on fructosamine than on glycated albumin.
We did not, however, see the same magnitude of attenuation upon adjustment for serum CRP concentration, which has been associated with CV events and subclinical atherosclerosis [ 31, 34].
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