Sentence examples for modification of breast from inspiring English sources

However, their results are compatible with the potential modification of breast cancer risk due to late age of menarche.

Additional investigation of a common SULT1A1 genetic polymorphism associated with reduced enzyme activity and stability might therefore provide deeper insight into the modification of breast cancer susceptibility.

Also, significant modification of breast cancer risk in BRCA1/2 mutation carriers was observed in association with selected low-penetrant risk alleles [ 41].

In this series of 2932 BRCA1/2 mutation carriers, no evidence of modification of breast or ovarian cancer risk by any of the two polymorphisms, Ins16bp and Arg72Pro, or their haplotype combinations has been detected.

The results did not provide any indication for a modification of breast cancer risk related to oestrogens by SULT1A1 genotype (data not shown) and corroborate recent evidence indicating that sulfonation of oestrogens catalyzed by SULT1A1 is less relevant in normal breast tissue in physiological conditions [ 11, 12].

Greater birth weights have been attributed to higher maternal estrogens levels, which could affect fetal development [ 72- 74] through epigenetic modifications of breast stem cells [ 1, 99, 100].

In the present study, we evaluated, separately for premenopausal and postmenopausal women, whether the CYP17 polymorphism was independently related to breast cancer risk or could possibly act through modification of other breast cancer risk factors.

The most clear-cut is modification of BRCA2-associated breast cancer risk by RAD51 [ 25], but other genes, including FGFR2, TNRC9, AURKA, and MAP3K1 [ 26- 28], have been suggested as risk modifiers.

The National Institute for Clinical Excellence ('NICE') guidelines appear to be more accurate than those of the Scottish Intercollegiate Guidelines Network ('SIGN') in defining 'moderate' familial risk, and longer follow-up of this cohort could generate an evidence base for further modification of familial breast cancer services.

This classification is a modification of the Breast Imaging Reporting and Data System (BI-RADS) where "fatty" corresponds to BI-RADS 1 (almost entirely fat), "moderate" to BI-RADS 2 + 3 (scattered fibroglandular densities; and heterogeneously dense) and "dense" to BI-RADS 4 (extremely dense) [ 30].

This is based on concerns about possible severe sequelae arising from a high total cumulative dose, exceeding normal tissue tolerance, being delivered to the portions of the breast that have presumably already received radiation for the lymphoma, even though modifications of the breast gland over time render the exact calculation of the dose infeasible many years after radiation delivery.