Sentence examples for modification of cancer from inspiring English sources

However, the scientific evidence regarding the modification of cancer risk continues to be debated.

The presence of genetic variations associated with altered enzymatic activity or expression of this metabolic pathway may result in significant changes in breast estrogen levels and subsequent modification of cancer risk.

Modification of cancer cells likely to reduce their immunogenicity, including loss or down-regulation of MHC molecules, is now well documented and has become the main support for the concept of immune surveillance.

This effect is not associated with a biologically less aggressive (low grade) tumor, but may be due to the modification of cancer progression and metastasis through the host's bone metabolism.

Some reports have demonstrated the induction of the immune response (such as phenotype modification of cancer cells and an increased susceptibility of cancer cells to effector cells) by siRNA-mediated therapy.

Promoter methylation and histone modification of cancer-related genes have played essential roles during carcinogenesis [ 17- 20].

Determining gene-specific patterns of histone modifications of cancer cells in primary tissue specimens can be cumbersome due to cellular heterogeneity and tissue quantity, and would involve high-throughput ChIP which may not be easily adaptable by clinical laboratories.

Most clinically distinguishable malignant tumors are characterized by specific mutations, specific patterns of chromosomal rearrangements and a predominant mechanism of genetic instability but it remains unsolved whether modifications of cancer genomes can be explained solely by mutations and selection through the cancer microenvironment.

Together, these oxygen-derived free radical species are able to induce several alterations and structure/function modifications of cancer-related proteins and gene mutations, including those related to cell-cycle control, apoptosis, lipid peroxidation, and DNA repair.

Results of the joint effect model are similar in both periods of prostate cancer diagnosis that is, there is statistically significant effect modification of prostate cancer risk in both the later and earlier follow-up periods.

In particular, this demonstrates that only models with k ≥ 3 cancer stages have parameters that can be altered without instantaneous modification of the cancer hazard.