Sentence examples for modification of antibodies from inspiring English sources

Although non-site-specific modification of antibodies does not interfere in most immunoassays, specific application and sensitive antibodies would benefit from site-specific biotinylation.

In some cases, modification of antibodies by mutagenesis increased binding to dsDNA but reduced pathogenicity [ 7].

This finding together with susceptibility of RTX to carbamylation strongly argues that inflammation-driven modification of antibodies may reduce effectiveness of biologics used to treat inflammatory diseases.

In order to gauge the impact of alkyne modification on exosomal function, a comparison can be drawn to the chemical modification of antibodies.

Small molecule modification of antibodies has been shown to have little to no effect on antibody binding affinities when approximately five or fewer modifications are made.

To explore the genetic diversity and the modification of antibody response in the recent outbreak of Ebola Virus.

Once these components are in hand, most ADCs are prepared by nonspecific modification of antibody lysine or cysteine residues with drug-linker reagents, which results in heterogeneous product mixtures that cannot be further purified.

Modifications of antibodies that change their charge or enable hydrophobic interactions with phospholipids in cellular membranes stimulate their internalization.

Glycoengineering and other modifications of antibodies to enhance their immune effector functions appear, therefore, to be a most effective way to improve the efficacy of naked antibody therapy by a variety of mechanisms.

Expressing antibodies as fusions to the non-self-cleaving Mxe GyrA intein enables site-specific, carboxy-terminal chemical modification of the antibodies by expressed protein ligation (EPL).

Another approach to the modification of monoclonal antibodies has been the addition of radionuclides.