Antibodies contain a conserved glycosylation site that has emerged as a target for the modulation of antibody effector functions.
Subtle modulation of antibody-binding properties by protein engineering often lies with an accurate structural and energetic description of how an antigen is recognised.
Sera from ΔN2mCHO(Q105N)_MPL immunized animals bound the homologous antigen ΔN2mCHO(Q105N) with greater preference than sera from ΔN2mCHO(QuilA)_Quimmunizedized animals, demonstrating the modulation of antibody fine specificity by these two adjuvants.
Based on the apparent enhancement of natural NK cytotoxicity by monocytes, we evaluated a potential modulation of antibody-dependent cellular cytotoxicity directed against different ovarian cancer cell lines.
In the future, effective botulinum toxin type A treatment may be restored in immunoresistant patients by epitope-selective modulation of antibody responses.
The synergistic therapeutic benefit in the combined use of pro-inflammatory immunocytokines and cytotoxic drugs may depend on several parameters, including the administration schedule, the modulation of antibody uptake at the tumour site, the selective damage to the endothelium and the activation or repression of specific immune cell subtypes (Moschetta et al, 2012).
Reverse transcription products containing RNA DNA hybrids could be sensed by TLR9, which has been implicated in pDC sensing of lentiviruses (Mandl et al, 2008) and in suppressing endogenous retrovirus (ERV -induced disERV -inducede modiseases of humoral antibody responses (Yu et al, 2012).
(5) Helminthic infections may reduce plasma LDL level not only by affecting the host nutrition, but also via modulation of naturally occurring antibodies to cholesterol.
Previous studies have shown that carriage of the sickle cell trait is associated with protection against uncomplicated malaria and with the modulation of anti-parasite antibody responses [18], [19], [20], [21], [22], therefore all the individuals carrying the HBB AS genotype (n = 32) were excluded from analyses that compared antibody responses between groups.
However, there was no difference in number of patients with positive response in HIV seropositive or seronegative groups indicating that HIV status may not be playing significant role in modulation of Cryptosporidium specific antibody responses.
Such antibodies may mediate their efficacy through both modulation of cellular proliferation and antibody-dependent immune functions (e.g. complement activation).
