Sentence examples for modification at one from inspiring English sources

Binding mode investigations suggested that the STLC scaffold can be used to develop new NS5B inhibitors by further chemical modification at one of the trityl phenyl group.

Although humans have influenced organic lineages in many ways, it is nonetheless reasonable to place synthetic biology towards one end of a continuum between purely 'blind' processes of organic modification at one extreme, and wholly rational, design-led processes at the other.

However, 74% of genes with no expression variation also displayed variable levels of histone modification at one or more enhancers.

Furthermore, it is difficult to discriminate between inter- vs. intra-molecular links or non-productive modifications arising from protein modification at one terminus of the cross-linker and, hydrolysis (for example) at the other.

Like 2-DG, 3-BrPA exhibited a potent cytotoxic activity against cancer cells with mitochondrial respiratory defects and against cells in a hypoxic environment [ 82]. 3-BrPA is believed to inhibit HKII through a covalent modification at one or more cysteine residues leading to an attenuation of the glycolytic rate [ 83].

In this case, mutations and chemical modifications at one position of the RNA can be considered as the interaction of a ligand.

Thus, modifications at one residue can influence the subsequent recruitment of interacting proteins that are themselves CTD effectors.

Our finding that the activity of a local sequence can be influenced by distal sequence provides a clear manner in which modifications at one part of the histone tail can affect subsequent modifications in a distal region.

Phenazine derivatives with chemical modifications at one or more positions of the aromatic ring structures have been identified, and most are due to one or a few terminal modifying enzymes.

Strand selection can be biased by designing asymmetric siRNAs with less stable thermodynamic stability at the 5′ end of the guide strand [ 59, 60], by chemical modifications at one or both ends of the siRNA [ 61, 62], or by the design of structurally asymmetric shRNAs or siRNAs that have a single 2-nucleotide 3′-overhang on the guide strand [ 63– 63].

Many motifs can function in isolation, however, in many cases, a binding or modification event at one motif will affect binding to or modification of another motif, i.e. motifs generally act co-operatively.