Thus, 83% (29 out of 35) of Wilms' tumours had alterations at one or more of the three loci.
With regard to the number of altered loci, 18 tumours (51%) showed alteration at only one locus and 11 (31%) showed alterations at multiple loci (Table 3).
The urine type I exam revealed proteinury in all the animals from the CG and in three animals from the TG during the evaluation period, with one animal from each group presenting this alteration at more than one moment.
Lesions (percentage of animals with severe integument alterations – at least one lesion or swelling) were observed especially in the hock region, in the cows kept in THSNE, the difference between the two housing systems being significant (t = - 6.65, P < 0.001, df = 78).
Microsatellite alterations were observed at one or more loci in 66.6% (14/21) of pancreatic cancers and in 26% (6/23) colon tumours, but all the pancreatic and half of the colon samples showed a low rate of microsatellite instability.
Up to 98 of those small RNA sequences showed alterations in their accumulation at one or another time point (Additional file 1: Table S1).
In total, 83% of the tumours had at least one alteration at 11p15.5 and/or 11p13.
After analyzing the signaling and growth phenotype of cells expressing only one alteration at a time, we engineered cells to express two alterations to study their combinatorial effect for BBC modeling.
Of the 35 studies that have investigated parameter uncertainty, univariate sensitivity analysis (i.e. alteration of one parameter at a time whilst holding others at their base-case value) was conducted by 43% (15 studies) [ 18, 28, 29, 43, 44, 46, 60, 63],[ 69, 77, 81, 83, 89, 91, 99].
The two substrate-binding sites appear to communicate with each other, and also with the nucleotide-binding site in the NBDs, as indicated by alterations in the binding affinity at one site when one of the others is occupied.
