Sentence examples for modest activity with from inspiring English sources

In conclusion, weekly schedule of docetaxel and gemcitabine has modest activity with acceptable toxicity profile in advanced NSCLC, but as high frequency of early discontinuation occurred does not merit further study with the present regimen.

Gemcitabine-based chemotherapy for locally advanced or metastatic PDAC has only modest activity with a small survival benefit [3].

In conclusion, temsirolimus appears to have only modest activity with a manageable toxicity profile in advanced NEC.

Mesa et al. demonstrated modest activity with a similar regimen, but no resolution of fibrosis was demonstrated.

The combination had modest activity, with PR in only two patients, and stable disease in 15 patients.

It was surprising to see the sulfone-linked analogue 49 exhibiting only modest activity with an IC50 value of 1787 n m.

However, the roots of Dichrostachys cinerea revealed modest activities with RSA of 27.4% [51].

Because replacement of W93 with alanine completely abolishes the catalytic activity of the enzyme with Co II Cbl, while modest activity is retained with Co(I Cbl, the W93A substitution likely affects the Co II)/Co(I) reduction step.

YM155 is a novel agent showing modest activity when combined with docetaxel for treating patients with melanoma.

While single agent HDACi treatment has only modest activity, drug combinations with chemotherapy have been studied, with some trials being positive [ 9], others being limited by toxicity of the combination [ 35].

Both these single-agent trials demonstrated that there was modest activity in patients with tumours that were derived from the oesophagus and GEJ with no objective responses seen in patients with distal stomach cancer.