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However, these drugs have a limited activity, with a response rate within a narrow range of 10%30%% [ 2– 5].
Among these, paclitaxel, docetaxel, topotecan, and temozolomide have shown only limited activity, with response rates of 5 17% in phase II studies (van Riel et al, 1999).
Similarly, our data suggest very limited activity with DES in poor performance, end-stage patients who previously received abiraterone.
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Although estramustine phosphate as a single agent showed limited activity, combination treatment with docetaxel revealed possible synergistic effects.
In conclusion, results from this single-arm phase II study suggest that panobinostat has only limited activity in patients with unselected STS.
However, mounting studies have shown their limited activity in cells with T790M mutations [ 2] given acquiring ligand-independent oncogenic potential [ 3], more aggressive tumor phenotype and affecting other pathways [ 4].
Commercial fishing, once concentrated in Lake Erie, with limited activity in the other large lakes, went into decline with the spread of pollution.
He suffers from spinal stenosis (a narrowing of the spinal canal) and is housebound many days, with limited activity on others.
Since the Lateglacial the Cormor system has been an intermittent stream with limited activity.
In addition to the media reports Tuesday, the sector was hurt by tough talk from President Obama, along with Goldman Sachs ' suggestion that the deepwater moratorium could last as long as a year, and continue with limited activity until 2012.
The selectivity shift towards oxygen evolution can be linked with limited activity of the Ru1−xCoxO2-y materials in the chlorine evolution reaction which seems to be relatively weakly dependent on the chloride concentration.
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