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Finally ecotoxicological data showed moderate toxicity in the initial leachates, with an increase coinciding with pesticide maximum concentration.
Although they display low to moderate toxicity in cells in culture, the underlying mechanisms of surfactant-mediated cytotoxicity are poorly investigated.
Amiodarone showed moderate toxicity in complete medium but induced extensive cell death in DPBS.
We found high rates of EFS, OS, LPFS, and DPFS with moderate toxicity in the majority of patients.
The active compounds exhibited very low to moderate toxicity in assays for their effects on cell viability (Table 2).
A recent phase I study showed that weekly cisplatin, irinotecan and concurrent radiotherapy can be administered with moderate toxicity in patients with oesophageal cancer.
Similar(54)
This regimen showed promising activity with moderate toxicities in advanced gastric cancer.
Three-week schedule of irinotecan/cisplatin showed effective antitumour activity and moderate toxicities in patients with previously untreated extensive-stage small-cell lung cancer.
In spite of the moderate toxicity of phenols in acute experiments, repeated administration of small doses can cause different changes in the nervous system and internal organs of experimental animals.
This regimen had moderate toxicity, and resulted in a median progression-free survival (PFS) of 14.2 months and median OS of 21.1 months.
Nine patients died in the moderate toxicity group and four patients died in the high toxicity group (P > 0.05).
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